{"7139eaa1-a3c8-41e6-8bea-bbf2be110df9":"What Are Polynucleotides?","8f4ed747-6538-42b3-9204-10e4e72f859a":"<p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">Polynucleotides are highly purified DNA fragments derived from salmon, selected for their close biological compatibility with human skin. They work at a cellular level to support the skin’s natural repair processes, strengthening tissue and improving skin quality from within. This is a regenerative treatment that focuses on restoring skin health, rather than simply treating the surface.</span></p>","9551510c-7e7c-4050-86b6-7d7743d053b7":"bg-navy","275f9f89-7d68-41ef-9e4d-b2f9f830d528":"Dr Rachel - The Science Behind Cellular Repair","09b096a5-3744-49b5-aca3-68c5a759cee3":"<p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">\"Every time I explain polynucleotides to patients, I often see a lightbulb moment. For many people, this treatment offers something that other aesthetic approaches cannot.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">While many traditional treatments focus on improving visible symptoms, polynucleotides work at a deeper level, supporting one of the key biological drivers of skin ageing: declining cellular function.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">As we age, fibroblasts - the cells responsible for producing collagen, elastin and hyaluronic acid - become less active. This contributes to thinning skin, reduced elasticity, dehydration and the tired, crepey appearance that is often most noticeable around delicate areas such as the under-eyes, where treatment options can be limited.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">Polynucleotides are highly purified DNA fragments derived from salmon. When carefully injected into human tissue, they encourage fibroblasts to become more active, supporting collagen production, improving microcirculation and helping repair cellular DNA damage caused by UV exposure and oxidative stress. By strengthening the skin from within, they also create a healthier foundation, making them an ideal primer before other collagen-stimulating treatments.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">In my clinic, I use premium, CE-marked products such as <strong>Plinest</strong>, selected for their safety, purity and clinical evidence. A typical course involves 3-4 treatments spaced 3-4 weeks apart, building a regenerative foundation within the skin. Improvements develop gradually, with results becoming most noticeable around <strong>12 weeks</strong> as the skin strengthens and renews.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">For menopausal skin, where thinning and dryness are influenced by declining oestrogen levels, polynucleotides offer targeted cellular support alongside hormonal management. Many of my Wirral patients in their 40s, 50s and 60s find this approach particularly helpful for restoring skin quality and resilience.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">This reflects the direction aesthetic medicine is moving in: supporting the skin to repair and regenerate itself, rather than simply addressing surface changes.\"</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\"><strong>— Dr Rachel Sinton, MBChB (Hons), MRCGP, GMC-Registered GP</strong></span></p>","00524f8a-98d9-4f47-b5d0-b4c407115118":[2583],"fb812f21-7614-47e0-b55a-8ed5607b5f4b":false,"556a3ac6-956d-48f1-b64a-184871e63dde":"Dr Rachel - Why doctor-led matters","c38db626-85ba-4201-9240-e8c2b19beb5e":"<p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">\"The under-eye area, where many patients choose polynucleotides, is one of the most delicate and technically demanding areas of the face. The skin is extremely thin, the vascular anatomy is complex, and careful assessment and precise technique are essential to minimise risk and achieve the best outcome.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">This is where doctor-led treatment matters.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">As a <strong>GMC-registered GP</strong> with over ten years of clinical experience, I bring medical training, diagnostic expertise and a detailed understanding of facial anatomy to every treatment. I am trained to recognise complications early and manage them appropriately, and just as importantly, to reduce the risk of complications through careful planning, anatomical knowledge and clinical judgement.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">I carry emergency equipment and hold full professional indemnity insurance for advanced injectable procedures. However, safety is not only about responding to problems; it is about preventing them. That starts with thorough assessment, correct product choice and precise technique.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">Before any treatment, I carry out a comprehensive medical consultation. I assess your skin quality, examine the anatomy around the under-eye area and discuss suitability in detail. In some cases, I may recommend alternative or complementary treatments, such as combining polynucleotides with <strong>pHformula medical skincare</strong> or <strong>microneedling</strong>, to support skin health more holistically.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">I am also a member of <strong>CMAC (Complications in Medical Aesthetics Collaborative)</strong>, ensuring that my practice remains aligned with the latest safety guidance and evidence-based protocols.</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\">Your face deserves expert care, careful judgement and a medical approach focused on safety as well as results.”</span></p><p><span style=\"background-color:transparent;color:hsl(0,0%,100%);\"><strong>— Dr Rachel Sinton, GMC-Registered GP &amp; CMAC Member</strong></span></p>","7509c6f1-b682-433b-9708-0d83e83f3a1f":[2582],"0e712616-4ff7-45e0-bd93-b25da08757d3":"\"I've had polynucleotides for my under-eyes for six months now and the transformation is incredible. My hereditary dark circles have significantly faded and my skin looks so much healthier. Dr Rachel explained everything thoroughly, and I felt completely confident in her expertise. This has genuinely changed how I feel about my face.\"","a0af3f1d-586c-4a0f-a63b-23905a40f7f4":"Emma, West Kirby","2b3e1715-32ff-447b-9460-6469aeb01c95":"Polynucleotides","662abfc6-cb86-492b-a40d-00775916402e":"E.","780ba720-3833-46e6-89d7-7d24cc606852":5,"80b2559f-f6ea-4425-a80c-d4905608eff9":"Why Choose Aesthetics by Dr Rachel?","2e2b47ba-c967-4b16-8293-07e5c74319fe":"<p><span style=\"background-color:transparent;color:#000000;\"> An award-winning, doctor-led aesthetic clinic specialising in natural, regenerative results across the Wirral. Advanced under-eye treatments demand a medical approach, expert assessment and precise technique.</span></p><p> </p>","bae8aad6-de36-441f-bb76-34f1e3a478b2":"Book Your Consultation","3ca08555-77e8-454e-8700-705a90cc539c":"/contacts"}